Article
Analysis of PALB2/FANCN-associated breast cancer families.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2007
Tischkowitz Marc, Xia Bing, Sabbaghian Nelly, Reis-Filho Jorge S, Hamel Nancy, Li Guilan, van Beers Erik H, Li Lili, Khalil Tayma, Quenneville Louise A, Omeroglu Atilla, Poll Aletta, Lepage Pierre, Wong Nora, Nederlof Petra M, Ashworth Alan, Tonin Patricia N, Narod Steven A, Livingston David M, Foulkes William D
Abstract excerpt
No more than approximately 30% of hereditary breast cancer has been accounted for by mutations in known genes. Most of these genes, such as BRCA1, BRCA2, TP53, CHEK2, ATM, and FANCJ/BRIP1, function in DNA repair, raising the possibility that germ line mutations in other genes that contribute to this process also predispose to breast cancer. Given its close relationship with BRCA2, PALB2 was sequenced in affected...
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