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Article

Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.

Breast cancer research and treatment - 1 Feb 2009

García María J, Fernández Victoria, Osorio Ana, Barroso Alicia, Llort Gemma, Lázaro Conxi, Blanco Ignacio, Caldés Trinidad, de la Hoya Miguel, Ramón Y Cajal Teresa, Alonso Carmen, Tejada María-Isabel, San Román Carlos, Robles-Díaz Luis, Urioste Miguel, Benítez Javier

Abstract excerpt

Recent reports have shown that mutations in the FANCJ/BRIP1 and FANCN/PALB2 Fanconi Anemia (FA) genes confer a moderate breast cancer risk. Discussion has been raised on the phenotypic characteristics of the PALB2-associated families and tumors. The role of FANCB in breast cancer susceptibility has not been tested to date. Likewise PALB2 mutation frequency has not been studied in Spanish population. We analyzed...

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Source

Identifiers

PMID: 18302019
DOI: 10.1007/s10549-008-9945-0

Genes

PALB2
FANCB
BRCA1
BRIP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.PMID 18302019Read ↗

Analysis of PALB2/FANCN-associated breast cancer families.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.Semantic proximity Read ↗

PALB2: a novel inactivating mutation in a Italian breast cancer family.Semantic proximity Read ↗

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.Semantic proximity Read ↗

Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.Semantic proximity Read ↗

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.Semantic proximity Read ↗

PALB2/FANCN: recombining cancer and Fanconi anemia.Semantic proximity Read ↗

Novel germline PALB2 truncating mutations in African American breast cancer patients.Semantic proximity Read ↗

Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases.Semantic proximity Read ↗

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