Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

Abstract excerpt

Inherited mutations in the BRCA2-interacting protein PALB2 are known to be associated with increased risks of developing breast cancer. To evaluate the contribution of PALB2 to familial breast cancer in the United States, we sequenced the coding sequences and flanking regulatory regions of the gene from constitutional genomic DNA of 1,144 familial breast cancer patients with wild-type sequences at BRCA1 and...

Topics

Join the communities discussing this publication.

• BRCA1 Protein
• BRCA2 Protein
• Breast Neoplasms, Male
• Family Health
• Fanconi Anemia Complementation Group N Protein