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Article

Novel germline PALB2 truncating mutations in African American breast cancer patients.

Cancer - 1 Mar 2012

Zheng Yonglan, Zhang Jing, Niu Qun, Huo Dezheng, Olopade Olufunmilayo I

Abstract excerpt

BACKGROUND: It has been demonstrated that the partner and localizer of breast cancer 2 (PALB2) acts as a bridging molecule between the breast cancer 1 (BRCA1) and BRCA2 proteins and is responsible for facilitating BRCA2-mediated DNA repair. Truncating mutations in the PALB2 gene reportedly are enriched in patients with Fanconi anemia and breast cancer in various populations. METHODS: The authors evaluated the...

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Source

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Identifiers

PMID: 21932393
DOI: 10.1002/cncr.26388
PMCID: PMC3244533

Genes

PALB2
BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Novel germline PALB2 truncating mutations in African American breast cancer patients.PMID 21932393Read ↗

Germline mutations in PALB2 in African-American breast cancer casesSemantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.Semantic proximity Read ↗

Rare germline mutations in PALB2 and breast cancer risk: a population-based study.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.Semantic proximity Read ↗

Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.Semantic proximity Read ↗

PALB2 sequence variants in young South African breast cancer patients.Semantic proximity Read ↗

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.Semantic proximity Read ↗

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