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Article

PALB2 analysis in BRCA2-like families.

Breast cancer research and treatment - 1 Jun 2011

Adank M A, van Mil S E, Gille J J P, Waisfisz Q, Meijers-Heijboer H

Abstract excerpt

BRCA2 and PALB2 function together in the Fanconi anemia (FA)-Breast Cancer (BRCA) pathway. Mono-allelic and bi-allelic BRCA2 and PALB2 mutation carriers share many clinical characteristics. Mono-allelic germline mutations of BRCA2 and PALB2 are risk alleles of female breast cancer and have also been reported in familial pancreatic cancer, and bi-allelic mutations cause a severe form of Fanconi anemia. In view of...

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Topics

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Share to Amino Acid Substitution
Share to BRCA2 Protein
Share to Breast Neoplasms, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to Germ-Line Mutation

Share to Ovarian Neoplasms

Share to Pancreatic Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 20582465
DOI: 10.1007/s10549-010-1001-1

Genes

PALB2
BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PALB2 analysis in BRCA2-like families.PMID 20582465Read ↗

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PALB2 and the risks for cancer: implications for clinical care.Semantic proximity Read ↗

Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.Semantic proximity Read ↗

Analysis of the Gene Coding for the BRCA2-Interacting Protein PALB2 in Familial and Sporadic Pancreatic CancerSemantic proximity Read ↗

Analysis of PALB2/FANCN-associated breast cancer families.Semantic proximity Read ↗

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.Semantic proximity Read ↗

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