The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.

doi:10.1158/1055-9965.EPI-13-0745-T

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Article

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2013

Janatova Marketa, Kleibl Zdenek, Stribrna Jana, Panczak Ales, Vesela Kamila, Zimovjanova Martina, Kleiblova Petra, Dundr Pavel, Soukupova Jana, Pohlreich Petr

Abstract excerpt

BACKGROUND: Several reports indicate that inherited mutations in the PALB2 gene predispose to breast cancer. However, there is little agreement about the clinical relevance and usefulness of mutation screening in this gene. We analyzed the prevalence and spectrum of germline mutations in PALB2 to estimate their contribution to hereditary breast and/or ovarian cancer in the Czech Republic. METHODS: The entire...

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Identifiers

PMID: 24136930
DOI: 10.1158/1055-9965.EPI-13-0745-T

Genes

PALB2
BRCA2
BRCA1
IMPACT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.PMID 24136930Read ↗

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