A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.

doi:10.1158/1055-9965.EPI-06-0776

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2007

Spurdle Amanda B, Chang Jiun-Horng, Byrnes Graham B, Chen Xiaoqing, Dite Gillian S, McCredie Margaret R E, Giles Graham G, Southey Melissa C, Chenevix-Trench Georgia, Hopper John L

Abstract excerpt

OBJECTIVE: We undertook a case-control study in an Australian Caucasian population-based sample of 1,246 cases and 664 controls to assess the roles of detoxification gene polymorphisms EPHX T>C Tyr(113)His, GSTT1 deletion, GSTM1 deletion, and GSTP1 A>G Ile(105)Val on risk of breast cancer. METHODS: We systematically addressed the main effects and possible gene-gene interactions using unconditional logistic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chi-Square Distribution

Share to Confounding Factors, Epidemiologic

Share to Epoxide Hydrolases

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Likelihood Functions

Share to Logistic Models

Source

Open in PubMed

Identifiers

PMID: 17416769
DOI: 10.1158/1055-9965.EPI-06-0776

Genes

GSTM1
GSTT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.PMID 17416769Read ↗

Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.Semantic proximity Read ↗

Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals.Semantic proximity Read ↗

Functional genomics based prioritization of potential nsSNPs in EPHX1, GSTT1, GSTM1 and GSTP1 genes for breast cancer susceptibility studies.Semantic proximity Read ↗

Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1.Semantic proximity Read ↗

CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer.Semantic proximity Read ↗

High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.Semantic proximity Read ↗

The microsomal epoxide hydrolase Tyr113His polymorphism: association with risk of ovarian cancer.Semantic proximity Read ↗

Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.Semantic proximity Read ↗

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

EPHX1 polymorphisms and the risk of lung cancer: a HuGE review.Semantic proximity Read ↗

Genetic polymorphisms of xenobiotic-metabolizing enzymes influence the risk of pulmonary emphysema.Semantic proximity Read ↗

Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.