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Article

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.

PloS one - 1 Jan 2012

Liu Fei, Yuan Ding, Wei Yonggang, Wang Wentao, Yan Lvnan, Wen Tianfu, Xu Mingqing, Yang Jiayin, Li Bo

Abstract excerpt

BACKGROUND: Microsomal epoxide hydrolase (EPHX1) plays an important role in both the activation and detoxification of PAHs, which are carcinogens found in cooked meat and tobacco smoking. Polymorphisms at exons 3 and 4 of the EPHX1 gene have been reported to be associated with variations in EPHX1 activity. The aim of this study is to quantitatively summarize the relationship between EPHX1 polymorphisms and...

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22928041
DOI: 10.1371/journal.pone.0043821
PMCID: PMC3426545

Genes

EPHX1

Provenance

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Related research

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Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.PMID 22928041Read ↗

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Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.Semantic proximity Read ↗

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Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.Semantic proximity Read ↗

Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.Semantic proximity Read ↗

Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.Semantic proximity Read ↗

Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.Semantic proximity Read ↗

Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.Semantic proximity Read ↗

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