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Article

Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.

American journal of respiratory cell and molecular biology - 1 Jul 2007

Reddy Narsa M, Kleeberger Steven R, Cho Hye-Youn, Yamamoto Masayuki, Kensler Thomas W, Biswal Shyam, Reddy Sekhar P

Abstract excerpt

Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/-)) show reduced pulmonary expression of several antioxidant enzymes, which renders them highly...

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Identifiers

PMID: 17413030
DOI: 10.1165/rcmb.2007-0004RC
PMCID: PMC1899352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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