Article
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Nature - 6 Jul 2011
DeNicola Gina M, Karreth Florian A, Humpton Timothy J, Gopinathan Aarthi, Wei Cong, Frese Kristopher, Mangal Dipti, Yu Kenneth H, Yeo Charles J, Calhoun Eric S, Scrimieri Francesca, Winter Jordan M, Hruban Ralph H, Iacobuzio-Donahue Christine, Kern Scott E, Blair Ian A, Tuveson David A
Abstract excerpt
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor Nrf2 (also known as Nfe2l2) and its repressor protein Keap1 (refs 2-5). In contrast to the acute physiological regulation of Nrf2, in neoplasia there is evidence for...
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