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Article

Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice.

Antioxidants & redox signaling - 15 Oct 2012

Cho Hye-Youn, van Houten Bennett, Wang Xuting, Miller-DeGraff Laura, Fostel Jennifer, Gladwell Wesley, Perrow Ligon, Panduri Vijayalakshmi, Kobzik Lester, Yamamoto Masayuki, Bell Douglas A, Kleeberger Steven R

Abstract excerpt

AIMS: Nrf2 is an essential transcription factor for protection against oxidant disorders. However, its role in organ development and neonatal disease has received little attention. Therapeutically administered oxygen has been considered to contribute to bronchopulmonary dysplasia (BPD) in prematurity. The current study was performed to determine Nrf2-mediated molecular events during saccular-to-alveolar lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22400915
DOI: 10.1089/ars.2011.4288
PMCID: PMC3423869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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