Temperature-sensitive mutants of p53 associated with human carcinoma of the lung.

Article

Temperature-sensitive mutants of p53 associated with human carcinoma of the lung.

Oncogene - 1 Jan 1992

Medcalf E A, Takahashi T, Chiba I, Minna J, Milner J

Abstract excerpt

We have compared the effects of specific point mutations on the tertiary and quaternary structure of the human p53 protein. Eight mutants, each derived from primary resected tissues of lung carcinomas, were expressed in vitro under strictly defined conditions, such that the only known variant was...

Topics

Carcinoma
Genes, p53
Humans
Lung Neoplasms
Mutation
Phenotype
Protein Biosynthesis
Protein Conformation
Temperature
Tumor Suppressor Protein p53

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