Conformational effects of selected cancer-related amino acid substitutions in the p53 protein.

doi:10.1080/07391102.1992.10508645

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Article

Conformational effects of selected cancer-related amino acid substitutions in the p53 protein.

Journal of biomolecular structure & dynamics - 1 Oct 1992

Brandt-Rauf P W, De Vivo I, Dykes D C, Pincus M R

Abstract excerpt

The tumor suppressor gene p53 has been identified as the most frequent target of genetic alterations in human cancers. Cancer-related mutations in the human p53 protein tend to cluster in four of the five highly conserved domains of the protein, and, in particular, in the central region of domain...

Topics

Amino Acid Sequence
Animals
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasms
Peptides
Protein Conformation
Protein Structure, Secondary
Tumor Suppressor Protein p53

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