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Article

Conformational effects of selected cancer-related amino acid substitutions in the p53 protein.

Journal of biomolecular structure & dynamics - 1 Oct 1992

Brandt-Rauf P W, De Vivo I, Dykes D C, Pincus M R

Abstract excerpt

The tumor suppressor gene p53 has been identified as the most frequent target of genetic alterations in human cancers. Cancer-related mutations in the human p53 protein tend to cluster in four of the five highly conserved domains of the protein, and, in particular, in the central region of domain IV from residues 241 to 253. Using conformational energy analysis based on ECEPP (Empirical Conformational Energies...

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Source

Identifiers

PMID: 1466808
DOI: 10.1080/07391102.1992.10508645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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