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Article

Mutant p53 proteins bind DNA abnormally in vitro.

Oncogene - 1 Jan 1991

Kern S E, Kinzler K W, Baker S J, Nigro J M, Rotter V, Levine A J, Friedman P, Prives C, Vogelstein B

Abstract excerpt

The p53 gene encodes a phosphoprotein which binds DNA. Many types of tumors contain mutant p53 genes, but the effects of these mutations on the intrinsic properties of p53 are largely unknown. In the present study, we tested the effect of p53 mutations on DNA-binding. Each of 15 different mutant p53 gene products derived from human tumors or mouse transformants bound calf thymus DNA more weakly than did wild-type...

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PMID: 1846954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant p53 proteins bind DNA abnormally in vitro.PMID 1846954Read ↗

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