Mutant p53 proteins bind DNA abnormally in vitro.

Article

Mutant p53 proteins bind DNA abnormally in vitro.

Oncogene - 1 Jan 1991

Kern S E, Kinzler K W, Baker S J, Nigro J M, Rotter V, Levine A J, Friedman P, Prives C, Vogelstein B

Abstract excerpt

The p53 gene encodes a phosphoprotein which binds DNA. Many types of tumors contain mutant p53 genes, but the effects of these mutations on the intrinsic properties of p53 are largely unknown. In the present study, we tested the effect of p53 mutations on DNA-binding. Each of 15 different mutant...

Topics

DNA
Genes, p53
Humans
In Vitro Techniques
Isoelectric Focusing
Mutation
Phosphoric Monoester Hydrolases
Salts
Transcription, Genetic
Tumor Suppressor Protein p53

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