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Article

Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae.

The EMBO journal - 5 Apr 2006

Dez Christophe, Houseley Jonathan, Tollervey David

Abstract excerpt

We previously hypothesized that HEAT-repeat (Huntington, elongation A subunit, TOR) ribosome synthesis factors function in ribosome export. We report that the HEAT-repeat protein Sda1p is a component of late 60S pre-ribosomes and is required for nuclear export of both ribosomal subunits. In strains carrying the ts-lethal sda1-2 mutation, pre-60S particles were rapidly degraded following transfer to 37 degrees C....

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Identifiers

PMID: 16541108
DOI: 10.1038/sj.emboj.7601035
PMCID: PMC1440318

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