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Article

Nuclear retention prevents premature cytoplasmic appearance of mRNA.

Molecular cell - 12 Oct 2012

Kallehauge Thomas Beuchert, Robert Marie-Cécile, Bertrand Edouard, Jensen Torben Heick

Abstract excerpt

In S. cerevisiae cells debilitated in mRNA nuclear export, transcripts are retained in nuclear foci ("dots"). The ultimate fate of dot-mRNA has remained elusive. Here, we use single molecule counting microscopy and (35)S-methionine pulse-labeling assays to quantify cytoplasmic HSP104 RNA levels and estimate HSP104 RNA translation status. HSP104 transcripts, retained in dots as a consequence of the mex67-5...

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Identifiers

PMID: 22921936
DOI: 10.1016/j.molcel.2012.07.022

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