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Article

The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell Repertoire

4 Apr 2007

Abstract excerpt

Immune function in the elderly is associated with a number of phenotypic and functional abnormalities, and this phenomenon of immune senescence is associated with increased susceptibility to infection. The immune response to pathogens frequently declines with age, but the CD8(+) T-cell response to cytomegalovirus (CMV) is unusual, as it demonstrates a significant expansion over time. Here we have documented the...

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PMID: 17409149
DOI: 10.1128/jvi.01262-06

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