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Article

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus.

Age (Dordrecht, Netherlands) - 1 Apr 2014

Vescovini Rosanna, Fagnoni Francesco Fausto, Telera Anna Rita, Bucci Laura, Pedrazzoni Mario, Magalini Francesca, Stella Adriano, Pasin Federico, Medici Maria Cristina, Calderaro Adriana, Volpi Riccardo, Monti Daniela, Franceschi Claudio, Nikolich-Žugich Janko, Sansoni Paolo

Abstract excerpt

Alterations in the circulating CD8+ T cell pool, with a loss of naïve and accumulation of effector/effector memory cells, are pronounced in older adults. However, homeostatic forces that dictate such changes remain incompletely understood. This observational cross-sectional study explored the basis for variability of CD8+ T cell number and composition of its main subsets: naïve, central memory and effector memory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24318918
DOI: 10.1007/s11357-013-9594-z
PMCID: PMC4039262

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