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Article

IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2015

Ferrando-Martínez Sara, Ruiz-Mateos Ezequiel, Casazza Joseph P, de Pablo-Bernal Rebeca S, Dominguez-Molina Beatriz, Muñoz-Fernández M Ángeles, Delgado Juan, de la Rosa Rafael, Solana Rafael, Koup Richard A, Leal Manuel

Abstract excerpt

Persistent cytomegalovirus (CMV) infection has been suggested to be a major driving force in the immune deterioration and an underlying source of age-related diseases in the elderly. CMV antibody titers are associated with lower responses to vaccination, cardiovascular diseases, frailty, and mortality. CMV infection is also associated with shorter T-cell telomeres and replicative senescence. Although an...

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Identifiers

PMID: 25238774
DOI: 10.1093/gerona/glu171
PMCID: PMC4612356

Genes

PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans.PMID 25238774Read ↗

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