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T Cell Replicative Senescence in Human Aging

23 Feb 2013

Abstract excerpt

The decline of the immune system appears to be an intractable consequence of aging, leading to increased susceptibility to infections, reduced effectiveness of vaccination and higher incidences of many diseases including osteoporosis and cancer in the elderly. These outcomes can be attributed, at least in part, to a phenomenon known as T cell replicative senescence, a terminal state characterized by dysregulated...

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PMID: 23061726
DOI: 10.2174/138161213805219711

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