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Article

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

28 Aug 2009

Abstract excerpt

BACKGROUND: Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that affect functionality of T cells and the differentiation and large expansions of CMV pp65-specific T cells have been associated with impaired responses to other immune challenges. Moreover, the presence of clonal expansions of CMV-specific T cells...

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PMID: 19715573
DOI: 10.1186/1742-4933-6-11

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