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Article

RNASEL Arg462Gln polymorphism and prostate cancer in PLCO.

The Prostate - 1 Jun 2007

Daugherty Sarah E, Hayes Richard B, Yeager Meredith, Andriole Gerald L, Chatterjee Nilanjan, Huang Wen-Yi, Isaacs William B, Platz Elizabeth A

Abstract excerpt

BACKGROUND: The Gln allele of the Arg462Gln polymorphism in RNASEL results in a threefold decrease in enzymatic activity, a reported deficiency in apoptotic response, and has been associated with prostate cancer in some high-risk family studies. The relationship of this variant to sporadic prostate cancer remains uncertain. METHODS: We conducted a nested case-control study of 1,317 prostate cancer cases and 1,842...

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Source

Identifiers

PMID: 17407163
DOI: 10.1002/pros.20537

Genes

RNASEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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