Article
Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study.
The Lancet. Oncology - 1 Aug 2005
Krüger Stefan, Silber Ann-Sophie, Engel Christoph, Görgens Heike, Mangold Elisabeth, Pagenstecher Constanze, Holinski-Feder Elke, von Knebel Doeberitz Magnus, Moeslein Gabriela, Dietmaier Wolfgang, Stemmler Susanne, Friedl Waltraut, Rüschoff Josef, Schackert Hans K
Abstract excerpt
BACKGROUND: RNASEL is thought to be a susceptibility gene for hereditary prostate cancer and encodes the endoribonuclease RNase L, which has a role in apoptosis and is a candidate tumour-suppressor protein. A common sequence variation in RNASEL, Arg462Gln, has been associated with hereditary and sporadic prostate cancer, and the Gln variant has about three-fold reduced RNase activity in vitro. In view of the...
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