Article
The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.
The Journal of experimental medicine - 1 Mar 1992
Jain J, Valge-Archer V E, Sinskey A J, Rao A
Abstract excerpt
Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes. We have examined the potential role of PKC in induction of the interleukin 2 (IL-2) gene in T cells stimulated through...
Topics
- Base Sequence
- Binding Sites
- Gene Expression Regulation
- Humans
- Interleukin-2
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Phorbol Esters
- Plasmids
- Promoter Regions, Genetic
- Protein Kinase C
- Proto-Oncogene Proteins c-jun
- T-Lymphocytes
- Transfection