Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.

The Journal of experimental medicine - 1 Mar 1992

Jain J, Valge-Archer V E, Sinskey A J, Rao A

Abstract excerpt

Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes. We have examined the potential role of PKC in induction of the interleukin 2 (IL-2) gene in T cells stimulated through the T cell receptor/CD3 complex. We have previously shown that prolonged treatment of the untransformed T cell clone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Promoter Regions, Genetic

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1740667
DOI: 10.1084/jem.175.3.853
PMCID: PMC2119150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.PMID 1740667Read ↗

Analysis of the AP-1 sites in the IL-2 promoter.Semantic proximity Read ↗

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.Semantic proximity Read ↗

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T LymphocytesSemantic proximity Read ↗

Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.Semantic proximity Read ↗

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T CellsSemantic proximity Read ↗

Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex.Semantic proximity Read ↗

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.Semantic proximity Read ↗

Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphocytes.Semantic proximity Read ↗

Mapping of polyomavirus middle T domain that is responsible for AP-1 activation.Semantic proximity Read ↗

Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter.Semantic proximity Read ↗

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.Semantic proximity Read ↗

MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.