Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphocytes.

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Article

Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphocytes.

Transplantation - 15 May 1995

Paliogianni F, Boumpas D T

Abstract excerpt

Glucocorticoids (GC) inhibit IL-2 gene transcription by interfering with the binding of the nuclear factor activator protein-1 on the IL-2 promoter. Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is an essential component of the T cell antigen receptor signal transduction pathway l...

Topics

Calcineurin
Calmodulin-Binding Proteins
Cells, Cultured
Dexamethasone
Gene Expression Regulation
Gene Transfer Techniques
Humans
Interleukin-2
Lymphocyte Activation
Mutation
Phosphoprotein Phosphatases
Signal Transduction
T-Lymphocytes
Transcription, Genetic

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Open in PubMed

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PMID: 7762070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7762070-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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