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Article

Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.

Molecular and cellular biology - 1 Oct 1995

Alroy I, Towers T L, Freedman L P

Abstract excerpt

T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels. We report here that 1,25(OH)2D3-mediated repression in Jurkat cells is cycloheximide resistant, suggesting that it is a direct transcriptional...

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Identifiers

PMID: 7565732
DOI: 10.1128/MCB.15.10.5789
PMCID: PMC230831

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Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.PMID 7565732Read ↗

1α,25‐Dihydroxyvitamin D<sub>3</sub> and a Variety of its Natural Metabolites Transcriptionally Repress Nuclear‐Factor‐κB‐Mediated Interleukin‐8 Gene ExpressionSemantic proximity Read ↗

Analysis of the AP-1 sites in the IL-2 promoter.Semantic proximity Read ↗

Time-Resolved Gene Expression Analysis Monitors the Regulation of Inflammatory Mediators and Attenuation of Adaptive Immune Response by Vitamin DSemantic proximity Read ↗

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.Semantic proximity Read ↗

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.Semantic proximity Read ↗

Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription factor IIB, in vitro.Semantic proximity Read ↗

Enhancers Located within Two Introns of the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D<sub>3</sub>Semantic proximity Read ↗

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Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.Semantic proximity Read ↗

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.Semantic proximity Read ↗

Transcriptional regulation of the IL-2 gene.Semantic proximity Read ↗

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