Article
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
Molecular and cellular biology - 1 Oct 1995
Alroy I, Towers T L, Freedman L P
Abstract excerpt
T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels. We report here that 1,25(OH)2D3-m...
Topics
- Amino Acid Sequence
- Base Sequence
- Calcitriol
- Cell Line
- DNA
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Humans
- Interleukin-2
- Molecular Sequence Data
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Receptors, Calcitriol
- Receptors, Retinoic Acid