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Article

MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1996

Whitehurst C E, Geppert T D

Abstract excerpt

TCR engagement stimulates the activation of the protein kinase Raf-1. Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2. Raf-1 activity promotes IL-2 production in activated T lymphocytes. Therefore, we sought to...

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PMID: 8557975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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