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Article

p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts.

The Journal of biological chemistry - 1 Jan 2000

Sorimachi Yuriko, Karigane Daiki, Ootomo Yukako, Kobayashi Hiroshi, Morikawa Takayuki, Otsu Kinya, Kubota Yoshiaki, Okamoto Shinichiro, Goda Nobuhito, Takubo Keiyo

Abstract excerpt

Hematopoietic stem cells (HSCs) and their progeny sustain lifetime hematopoiesis. Aging alters HSC function, number, and composition and increases risk of hematological malignancies, but how these changes occur in HSCs remains unclear. Signaling via p38 mitogen-activated kinase (p38MAPK) has been proposed as a candidate mechanism underlying induction of HSC aging. Here, using genetic models of both chronological...

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Identifiers

PMID: 33745970
DOI: 10.1016/j.jbc.2021.100563
PMCID: PMC8065231

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