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Bone Marrow Mesenchymal Stem Cells Carrying FANCD2 Mutation Differ from the Other Fanconi Anemia Complementation Groups in Terms of TGF-β1 Production.

Stem cell reviews and reports - 1 Jun 2018

Cagnan Ilgin, Gunel-Ozcan Aysen, Aerts-Kaya Fatima, Ameziane Najim, Kuskonmaz Baris, Dorsman Josephine, Gumruk Fatma, Uckan Duygu

Abstract excerpt

Transforming growth factor beta (TGF-β) secretion from cells in the bone marrow (BM) niche affects hematopoietic stem cell (HSC) fate and has a cardinal role in HSC quiescence. BM mesenchymal stem cells (BM-MSCs), a component of the BM niche, may produce abnormal levels of TGF-β in Fanconi anemia (FA) and may play a role in bone marrow failure. Here, we molecularly and cellularly characterized FA BM-MSCs by...

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Source

Identifiers

PMID: 29247345
DOI: 10.1007/s12015-017-9794-5

Genes

FANCD2
FANCA
FANCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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