Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.

doi:10.1038/s41467-021-24876-1

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Article

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.

Nature communications - 27 Jul 2021

Biavasco Riccardo, Lettera Emanuele, Giannetti Kety, Gilioli Diego, Beretta Stefano, Conti Anastasia, Scala Serena, Cesana Daniela, Gallina Pierangela, Norelli Margherita, Basso-Ricci Luca, Bondanza Attilio, Cavalli Giulio, Ponzoni Maurilio, Dagna Lorenzo, Doglioni Claudio, Aiuti Alessandro, Merelli Ivan, Di Micco Raffaella, Montini Eugenio

Abstract excerpt

Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ dissemination of pro-inflammatory myeloid cells. Here, we generate a humanized mouse model of transplantation of human hematopoietic stem and progenitor cells (HSPCs) expressing the activated form of BRAF (BRAFV600E). All mice transplanted with BRAFV600E-expressing...

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PMID: 34315896
DOI: 10.1038/s41467-021-24876-1
PMCID: PMC8316479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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