Article
Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.
The EMBO journal - 1 Jan 1992
Hardin P E, Hall J C, Rosbash M
Abstract excerpt
Mutations in the disconnected (disco) gene act to disrupt neural cell patterning in the Drosophila visual system. These mutations also affect adult locomotor activity rhythms, as disco flies are arrhythmic under conditions of constant darkness (DD). To determine the state of the circadian pacemaker in disco mutants, we constructed with pers double mutants (a short period allele of the period gene) and assayed...
Topics
- Activity Cycles
- Animals
- Behavior, Animal
- Biological Clocks
- Circadian Rhythm
- Drosophila melanogaster
- Light
- Locomotion
- Models, Biological
- Mutation
- Periodicity
- RNA, Messenger