Article
Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression.
The European journal of neuroscience - 1 Mar 2001
Blanchardon E, Grima B, Klarsfeld A, Chélot E, Hardin P E, Préat T, Rouyer F
Abstract excerpt
The ventral lateral neurons (LNvs) of the Drosophila brain that express the period (per) and pigment dispersing factor (pdf) genes play a major role in the control of circadian activity rhythms. A new P-gal4 enhancer trap line is described that is mostly expressed in the LNvs This P-gal4 line was used to ablate the LNvs by using the pro-apoptosis gene bax, to stop PER protein oscillations by overexpressing per...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.