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Article

Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.

Molecular and cellular biology - 1 Oct 1997

Majercak J, Kalderon D, Edery I

Abstract excerpt

Drosophila melanogaster bearing mutations in the DCO gene, which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), displays arrhythmic locomotor activity strongly suggesting a role for PKA in the circadian timing system. This arrhythmicity might result from a requirement for PKA activity in photic resetting pathways, the timekeeping mechanism itself, or downstream effector pathways...

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Identifiers

PMID: 9315649
DOI: 10.1128/MCB.17.10.5915
PMCID: PMC232439

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