Article
Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis of survival in 619 female patients.
Lung cancer (Amsterdam, Netherlands) - 1 Aug 2007
Matakidou Athena, El Galta Rachid, Webb Emily L, Rudd Matthew F, Bridle Helen, Eisen Tim, Houlston Richard S
Abstract excerpt
The prognostic significance of the Arg72Pro polymorphism of the p53 tumour suppressor gene in cancer is controversial. To determine whether Arg72Pro is a marker for lung cancer prognosis we genotyped 619 female lung cancer patients with incident disease and examined the relationship between genotype and overall survival (OS). Nonparametric tests provided no evidence for a relationship between SNP genotype and OS...
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