Article
Frequency of TP53 mutations in relation to Arg72Pro genotypes in non small cell lung cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2007
Lind Helge, Ekstrøm Per Olaf, Ryberg David, Skaug Vidar, Andreassen Tove, Stangeland Lodve, Haugen Aage, Zienolddiny Shanbeh
Abstract excerpt
Mutations in the TP53 gene are important events during human lung carcinogenesis. The TP53 gene harbors several polymorphisms, and functional studies have shown that the Arg72Pro polymorphism alters both wild-type and mutant p53 protein activity. Thus, we hypothesized that certain Arg72Pro genotypes may influence the frequency and pattern of somatic mutations in TP53. We therefore examined the status of the...
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