Article
LOH rather than genotypes of TP53 codon 72 is associated with disease-free survival in primary breast cancer.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2006
Kyndi Marianne, Alsner Jan, Hansen Lise Lotte, Sørensen Flemming Brandt, Overgaard Jens
Abstract excerpt
Mutations in the TP53 gene are a well-documented strong prognostic factor in breast cancer. A prognostic value of the Arg72Pro polymorphism of the TP53 gene is more contradictory. We assessed TP53 mutations and genotypes of the Arg72Pro polymorphism in a study including 204 Danish women. Patients with mutations in the TP53 gene had a significant reduction in disease-free survival of breast cancer (p < 0.0001)....
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