Article
The influence of a metastable structure in plasmid primer RNA on antisense RNA binding kinetics.
Nucleic acids research - 25 Sept 1995
Gultyaev A P, van Batenburg F H, Pleij C W
Abstract excerpt
Replication of the ColE1 group plasmids is kinetically regulated by the interaction between plasmid-encoded primer RNA II and antisense RNA I. The binding is dependent on alternative RNA II conformations, formed during the transcription, and effectively inhibits the primer function within some time interval. In this paper, the folding pathways for the wild type and copy number mutants of ColE1 RNA II are studied...
Topics
- Algorithms
- Bacteriocin Plasmids
- Base Sequence
- Computer Simulation
- Gene Dosage
- Kinetics
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA