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Article

LNA Thymidine Monomer Enables Differentiation of the Four Single-Nucleotide Variants by Melting Temperature.

Journal of the American Chemical Society - 24 May 2017

Obliosca Judy M, Cheng Sara Y, Chen Yu-An, Llanos Mariana F, Liu Yen-Liang, Imphean Darren M, Bell David R, Petty Jeffrey T, Ren Pengyu, Yeh Hsin-Chih

Abstract excerpt

High-resolution melting (HRM) analysis of DNA is a closed-tube single-nucleotide polymorphism (SNP) detection method that has shown many advantages in point-of-care diagnostics and personalized medicine. While recently developed melting probes have demonstrated significantly improved discrimination of mismatched (mutant) alleles from matched (wild-type) alleles, no effort has been made to design a simple melting...

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Identifiers

PMID: 28463488
DOI: 10.1021/jacs.7b03395
PMCID: PMC5850941

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Source receipt: pubmed, retrieved 7 Sept 2026.

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