Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2006

Gaedigk Andrea, Bradford L Dianne, Alander Sarah W, Leeder J Steven

Abstract excerpt

Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered. In previous studies, several African Americans with a poor metabolizer phenotype carried the reduced function CYP2D6*10 allele in combination with a nonfunctional allele. We pursued the possibility that these alleles harbor either a known sequence variation (i.e., CYP2D6*36 carrying a gene conversion in exon 9 along the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Dextromethorphan

Share to Gene Duplication

Share to Gene Frequency

Share to Gene Rearrangement

Share to Infant

Source

Identifiers

PMID: 16415111
DOI: 10.1124/dmd.105.008292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.PMID 16415111Read ↗

Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.Semantic proximity Read ↗

CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing.Semantic proximity Read ↗

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.Semantic proximity Read ↗

Identification of CYP2D6 impaired functional alleles in Mexican Americans.Semantic proximity Read ↗

CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.Semantic proximity Read ↗

New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes.Semantic proximity Read ↗

Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population.Semantic proximity Read ↗

CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.Semantic proximity Read ↗

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.Semantic proximity Read ↗

Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events.Semantic proximity Read ↗

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.Semantic proximity Read ↗

CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.