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Article

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

The pharmacogenomics journal - 1 Jan 2005

Gaedigk A, Bhathena A, Ndjountché L, Pearce R E, Abdel-Rahman S M, Alander S W, Bradford L DiAnne, Rogan P K, Leeder J Steven

Abstract excerpt

Cytochrome P4502D6 (CYP2D6) genotyping reliably predicts poor metabolizer phenotype in Caucasians, but is less accurate in African Americans. To evaluate discordance we have observed in phenotype to genotype correlation studies, select African American subjects were chosen for complete resequencing of the CYP2D6 gene including 4.2 kb of the CYP2D7-2D6 intergenic region. Comparisons were made to a CYP2D6(*)1...

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Identifiers

PMID: 15768052
DOI: 10.1038/sj.tpj.6500305
PMCID: PMC1440720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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