Article
Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Mar 2007
López-Bendito Guillermina, Flames Nuria, Ma Le, Fouquet Coralie, Di Meglio Thomas, Chedotal Alain, Tessier-Lavigne Marc, Marín Oscar
Abstract excerpt
The function of the nervous system depends on the precision of axon wiring during development. Previous studies have demonstrated that Slits, a family of secreted chemorepellent proteins, are crucial for the proper development of several major forebrain tracts. Mice deficient in Slit2 or, even more so, in both Slit1 and Slit2 have defects in multiple axonal pathways, including corticofugal, thalamocortical, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.