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Article

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.

Neuron - 1 Dec 2000

Simpson J H, Kidd T, Bland K S, Goodman C S

Abstract excerpt

Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robo mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robo,...

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Source

Identifiers

PMID: 11163264
DOI: 10.1016/s0896-6273(00)00151-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.PMID 11163264Read ↗

Slit is the midline repellent for the robo receptor in Drosophila.Semantic proximity Read ↗

Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.Semantic proximity Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

To cross or not to cross: a genetic analysis of guidance at the midline.Semantic proximity Read ↗

Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.Semantic proximity Read ↗

Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.Semantic proximity Read ↗

Repellent signaling by Slit requires the leucine-rich repeats.Semantic proximity Read ↗

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