Article
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Neuron - 17 Jan 2002
Bagri Anil, Marín Oscar, Plump Andrew S, Mak Judy, Pleasure Samuel J, Rubenstein John L R, Tessier-Lavigne Marc
Abstract excerpt
We report that Slit proteins, a family of secreted chemorepellents, are crucial for the proper development of several major forebrain tracts. Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of pathways, including corticofugal, callosal, and thalamocortical tracts. Analysis of multiple pathways suggests several generalizations...
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