Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slit is the midline repellent for the robo receptor in Drosophila.

Cell - 19 Mar 1999

Kidd T, Bland K S, Goodman C S

Abstract excerpt

Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on growth cones that binds to an unknown midline ligand. Here we present genetic evidence that Slit is the midline Robo ligand; a companion paper presents biochemical evidence that Slit binds Robo. Slit is a large extracellular matrix protein expressed by midline glia. In slit mutants, growth cones enter the midline but never leave...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Body Patterning
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insect Proteins

Share to Ligands

Share to Open Reading Frames

Share to Receptors, Immunologic

Share to Roundabout Proteins

Source

Identifiers

PMID: 10102267
DOI: 10.1016/s0092-8674(00)80589-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slit is the midline repellent for the robo receptor in Drosophila.PMID 10102267Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

Repellent signaling by Slit requires the leucine-rich repeats.Semantic proximity Read ↗

Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.Semantic proximity Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.Semantic proximity Read ↗

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.