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Article

Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals.

Development (Cambridge, England) - 1 Nov 2008

Farmer W Todd, Altick Amy L, Nural Hikmet Feyza, Dugan James P, Kidd Thomas, Charron Frédéric, Mastick Grant S

Abstract excerpt

Longitudinal axons transmit all signals between the brain and spinal cord. Their axon tracts through the brain stem are established by a simple set of pioneer axons with precise trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or genetic deletion of the...

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Identifiers

PMID: 18842816
DOI: 10.1242/dev.023325
PMCID: PMC2768610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals.PMID 18842816Read ↗

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Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.Semantic proximity Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion.Semantic proximity Read ↗

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