Article
Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.
Development (Cambridge, England) - 1 Oct 2005
Hammond Rachel, Vivancos Valerie, Naeem Arifa, Chilton John, Mambetisaeva Elvira, Mambitisaeva Elvira, Andrews William, Sundaresan Vasi, Guthrie Sarah
Abstract excerpt
The floor plate is known to be a source of repellent signals for cranial motor axons, preventing them from crossing the midline of the hindbrain. However, it is unknown which molecules mediate this effect in vivo. We show that Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed by cranial motoneurons, and Slit proteins are expressed by the tissues that delimit motor...
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