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Article

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease.

Journal of neuroscience research - 1 Sept 2007

García-Martínez Juan M, Pérez-Navarro Esther, Xifró Xavier, Canals Josep M, Díaz-Hernández Miguel, Trioulier Yael, Brouillet Emmanuel, Lucas José J, Alberch Jordi

Abstract excerpt

Apoptosis, a cell death mechanism regulated by Bcl-2 family members, has been proposed as one of the mechanisms leading to neuronal loss in Huntington's disease (HD). Here we examined the regulation of Bcl-2 family proteins in three different mouse models of HD with exon 1 mutant huntingtin: the R6/1, the R6/1:BDNF+/-, and the Tet/HD94 in which the huntingtin transgene is controlled by the tetracycline-inducible...

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Identifiers

PMID: 17387706
DOI: 10.1002/jnr.21258

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease.PMID 17387706Read ↗

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