Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration.

Journal of neuroscience research - 1 Dec 2003

Bouillet Philippe, Robati Mikara, Adams Jerry M, Strasser Andreas

Abstract excerpt

Lurcher (lc) mice have a semi-dominant mutation in the gene encoding the delta2 glutamate receptor (GRID2). The resulting constitutive activity of this receptor in heterozygous +/lc (grid(+/lc)) and homozygous (grid(lc/lc)) mice leads to the death of all cerebellar Purkinje cells and most afferen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Apoptosis Regulatory Proteins
Share to Bcl-2-Like Protein 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Cerebellum

Share to Mice, Neurologic Mutants

Share to Nerve Degeneration

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 14635229
DOI: 10.1002/jnr.10805

Genes

GRID2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14635229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration.PMID 14635229Read ↗

Mitochondrial Morphogenesis, Dendrite Development, and Synapse Formation in Cerebellum Require both Bcl-w and the Glutamate Receptor δ2Semantic proximity Read ↗

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.Semantic proximity Read ↗

The Lurcher mouse: fresh insights from an old mutant.Semantic proximity Read ↗

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice.Semantic proximity Read ↗

Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse.Semantic proximity Read ↗

The lurcher gene induces apoptotic death in cerebellar Purkinje cells.Semantic proximity Read ↗

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor.Semantic proximity Read ↗

Cell death in weaver mouse cerebellum.Semantic proximity Read ↗

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.Semantic proximity Read ↗

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.Semantic proximity Read ↗

Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice.Semantic proximity Read ↗

Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.