Article
Bim contributes to the progression of Huntington's disease-associated phenotypes.
Human molecular genetics - 15 Jan 2020
Roberts Sheridan L, Evans Tracey, Yang Yi, Fu Yuhua, Button Robert W, Sipthorpe Rebecca J, Cowan Katrina, Valionyte Evelina, Anichtchik Oleg, Li Huiliang, Lu Boxun, Luo Shouqing
Abstract excerpt
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant HTT (mHTT) toxicity is caused by its aggregation/oligomerization. The striatum is the most vulnerable region, although all brain regions undergo neuronal degeneration in the disease. Here we show that the levels of Bim, a BH3-only protein, are significantly increased in HD...
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