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Article

Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS.

Molecular and cellular neurosciences - 1 Aug 2002

Guégan Christelle, Vila Miquel, Teismann Peter, Chen Caiping, Onténiente Brigitte, Li Mingwei, Friedlander Robert M, Przedborski Serge, Teissman Peter

Abstract excerpt

Transgenic expression of mutant superoxide dismutase-1 (SOD1) produces an animal model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. We have previously shown that the mitochondrial-dependent programmed cell death (PCD) pathway, including the redistribution of Bax, the cytosolic release of cytochrome c, and the activation of caspase-9, is recruited during neurodegeneration in spinal...

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Source

Identifiers

PMID: 12213439
DOI: 10.1006/mcne.2002.1136

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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